Scleroderma is a connective tissue disease that hardens the skin and scars the organs. Older men with scleroderma had higher estrogen levels than healthy older men or postmenopausal women with scleroderma, report researchers. Higher estradiol levels were associated with more severe disease and heart involvement in these men and, in those positive for the autoantibody Scl-70, a greater risk of death.
Higher estrogen levels linked to more severe disease in scleroderma
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