To the Editor: Type 1 diabetes is caused by insulin deficiency resulting from immune-mediated destruction of pancreatic beta cells. Its cause is multifactorial, with complex genetic factors and a strong influence of certain HLA types that probably indicates T-cell–mediated disease. Despite attempts…
STAT1 Gain of Function, Type 1 Diabetes, and Reversal with JAK Inhibition
To the Editor: Type 1 diabetes is caused by insulin deficiency resulting from immune-mediated destruction of pancreatic beta cells. Its cause is multifactorial, with complex genetic factors and a strong influence of certain HLA types that probably indicates T-cell–mediated disease. Despite attempts…