Precise experiments have revealed for the first time how Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), progresses on a…
Genome-wide analysis reveals new strategies to target pancreatic cancer
An international team of scientists employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the…
Cancer exports molecular ‘saboteurs’ to remotely disarm immune system
Immunotherapy drugs known as checkpoint inhibitors have revolutionized cancer treatment: many patients with malignancies that until recently would have been…
Insulin receptor and gene expression
Insulin triggers genome-wide changes in gene expression via an unexpected mechanism. The insulin receptor is transported from the cell surface…
Research improves understanding of new form of cell-cell communication
Scientists have improved their understanding of a new form of cell-cell communication that is based on extracellular RNA (exRNA) by…
Blocking epigenetic Swiss army knife may be a new strategy for treating colorectal cancer
A new study shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing…
Poverty leaves a mark on our genes
In this study, researchers found evidence that poverty can become embedded across wide swaths of the genome. They discovered that…
Using a promiscuous inhibitor to uncover cancer drug targets
Scientists have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
To keep the creative juices flowing, employees should be receptive to criticism
Though most firms today embrace a culture of criticism, when supervisors and peers dispense negative feedback it can actually stunt…
Severe psychological distress and daily cannabis use: Implications for mental health?
Daily cannabis use increased significantly from 2008 to 2016 among those with and without past-month serious psychological distress (SPD) and…