Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower cholesterol, block this metabolic pathway and cause the cancer cells to die, as scientists have now discovered. The researchers now intend to investigate this potential treatment strategy in more detail in cancer cells and animal experiments.
Metabolic adaptation ensures survival of colon cancer cells
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